Istituto Rudy Lanza - Catalogo bibliografico delle tesi

La Leaky Gut Syndrome (LGS), letteralmente Sindrome dell’intestino gocciolante, è un aumento della permeabilità della mucosa intestinale causata da uno stato infiammatorio cronico alla cui origine vi sono molti fattori ambientali ed abitudini alimentari errate tipiche della vita di oggi. Tale aumento, più o meno importante, della permeabilità della mucosa intestinale fà sì che alcune particelle estranee (per esempio molecole di cibo non completamente digerite), dopo aver attraversato la mucosa intestinale, entrino nel flusso sanguigno provocando la reazione del Sistema Immunitario che le attacca generando una risposta immunitaria ed infiammatoria. Per questo motivo la LGS è considerata la principale causa delle intolleranze alimentari.

In realtà l’alterata permeabilità consente anche a tossine, batteri, funghi e parassiti, che in condizioni normali non potrebbero attraversare la mucosa intestinale, di superare la barriera protettiva e di entrare nel sangue. Se la quantità di queste sostanze anomale dovesse superare la normale capacità di detossificazione dell’organismo, si genererebbe un’alterazione della funzionalità di fegato e reni con relativa insorgenza di tipiche sintomatologie da intossinazione, tra cui: confusione, perdita di memoria, mente annebbiata, sudore al volto.

Negli USA tale perdita di impermeabilità della mucosa intestinale è conosciuta, studiata e fortemente sospettata di essere all’origine non solo delle intolleranze ed allergie alimentari ma di molti altri disturbi funzionali e patologie vere e proprie quali: malattia celiaca, candidosi, problemi digestivi, fatica cronica, asma, mal di testa, artrite, malattie autoimmuni ed addirittura alcuni studi hanno individuato una correlazione con l’insorgenza di psoriasi ed autismo.

Prova ne è che facendo una ricerca in www.google.it con leaky gut syndrome, vengono dati oltre 100000 riferimenti oltre all’indicazione di ricerche correlate con le seguenti voci: leaky bowel syndrome, leaky gut syndrome reumathoid arthritis, leak gut syndrome allergies, leak gut syndrome celiac diseases, leak gut syndrome autism, leak gut syndrome symtoms, leaky gut syndrome supplement, leaky gut syndrome eczema.

Ciononostante in Italia essa è pressocchè sconosciuta, in particolare presso la categoria medica.

Questa tesi si propone pertanto di raccogliere la letteratura esistente in materia al fine di approfondire le cause ma soprattutto le conseguenze, talvolta inaspettate, della LGS per imparare a conoscerla ma soprattutto a riconoscerla.

Infine vengono proposti alcuni protocolli naturopatici per prevenirla e/o tenerla sotto controllo.

Bibliografia:

Cos’è la Leaky Gut Syndrome

Siti WEB :

• [Rif. 1] www.leakygut.co.uk/
• [Rif. 2] www.ei-resource.org/illness-information/environmental-illnesses/leaky-gut-syndrome-(lgs)/
• [Rif. 3] www.procaduceo.org/it_ricerche/anat_fisio/anat_fisio06.htm/
• [Rif. 4] www.drweil.com/drw/u/QAA361058/what-is-leaky-gut.html/
• [Rif. 5] http://altmedicine.about.com/od/healthconditionsdisease/a/TestLeakyGut.htm
• [Rif. 6] www.crohns.net/Miva/education/leakygut.shtml
• [Rif. 7] www.wisegeek.com/what-is-Leaky-Gut-Syndrome.htm
• [Rif. 8] http://mold-survivor.com/leaky_gut_syndrome.html
• [Rif. 9] www.pureliquidgold.com/leaky_gut_syndrome.htm

• [Rif. 10] www.ei-resource.org/articles/leaky-gut-syndrome-articles

• /intestinal-permeability-or-leaky-gut/

• /what-is-leaky-gut-syndrome?/
• /leaky-gut-syndrome-%11-dr-rajendra-sharma/
• /feeling-that-your-vitality-is-leaking-away?/
• /leaky-gut-syndrome:-the-intestinal-terrorist/
• /does-your-gut-leak?/

Cause, Sintomi e Conseguenze della Leaky Gut Syndrome

Siti WEB:

• [Rif. 11] www.leakygut.co.uk/symptoms.htm
• [Rif. 12] www.leakygut.co.uk/Causes.htm
• [Rif. 13] www.ei-resource.org/articles/leaky-gut-syndrome-articles/leaky-gut-syndrome:-the-systemic-consequences-of-faulty-digestion/
• [Rif. 14] www.autismmedical.com/gateway_2/
• [Rif. 15] www.ei-resource.org/illness-information/environmental-illnesses/fibromyalgia-(fms)/
• [Rif. 16] www.ei-resource.org/illness-information/environmental-illnesses/chronic-fatigue-syndrome-cfs-myalgic-encephalopathy-me/
• [Rif. 17] http://mold-survivor.com
• /lupus.html
• /Alopecia%20areata.html
• /arthritis.html
• /Polymyalgia.html
• /multiple_sclerosis.html
• /fibromyalgia.html
• /chronicfatigue.html
• /ss.html
• /Vitiligo.html
• /Thyroiditis.html
• /Vasculitis-2.html
• /crohn.html
• /Ulcerative%20Colitis.html
• /hives.html
• /diabetes.html
• /raynaud.html
• [Rif. 18] www.pureliquidgold.com/allergies.htm
• [Rif. 19] www.simaiss.it/PDF/articoli/La%20pancia%20stressata.pdf
• [Rif. 20] Alcoholism’s “Leaky Gut Syndrome” - M. Occhipinti- http://www.afpafitness.com/alcohol.html
• [Rif. 21] http://psoriasi-ricercaindipendente.blogspot.com/
• [Rif. 22] http://www.emergenzautismo.org/content/view
• [Rif. 23] http://www.demariani.it/autismo-e-nutrizione

Pubblicazioni su riviste scientifiche ed E-Paper:

• [Rif. 24] Abnormal intestinal permeability in Crohn’s diesease - G. Olaison et al. - Scand J Gastroenterol 25:321-28, 1990
• [Rif. 25] Intestinal permeability in chikdern with Crohn’s diesease and coeliac disease - A.D.J. Pearson, E.J. Eastham, M.F. Laker, A.W.Craft - Br Med J 285: 20-21, 1982
• [Rif. 26] Improvement of abnormal lactulose / rhamnose permeability in active Crohn’s disease of the small bowel by an elemental diet - I.R. Sanderson, P. Boulton, I. Menzies, J.A. Walker-Smith - Gut 28: 1073-76, 1987
• [Rif. 27] Relationship between intestinal permeability to (51Cr) EDTA and inflammatory in asymtomatic patients withnCrohn’s disease - L.Pironi, M.Miglioli, E. Ruggeri et al. - Dig Dis Sci 35:582-88, 1993
• [Rif. 28] Do non-steroidal anti-inflammatory drugs increase colonic permeability? - A.P. Jenkins, D.R. Trew, B. J. Crump et al. - Gut 32:66-69, 1991
• [Rif. 29] Dr.Braly’s Food Allergy & Nutrition Revolution- J.M.D. Braly - Keats Publishing, Inc., New Canan, Connecticut, 1992
• [Rif. 30] The leaky gut of alcoholism: possible route of entry for toxic compounds- I. Bjarnason, TJ peters, RJ Wise - Lancet, 28:1(8370):179-82, 1984
• [Rif. 31] Intestinal permeability is increased in burn patients shortlyafter injury - E.A. Deitch. - Surgery 107:411-16, 1990
• [Rif. 32] Aging-associated increase in intestinal absorption of macro-molecules - D. Hollander, H, Tarnawsky - Gerontology 31:133-37, 1985
• [Rif. 33] Chronic fatigue and Chronic fatigue sindrome. Prevalence in a Pacific Nothwest health care system - Buchwald D. Et al. - Ann Int Med 123:81-88, 1995
• [Rif. 34] A medical food-supplemented detoxification program in the management of chronic health problems - Bland J.S. et al - Alt Terapies 1:62-71, 1995
• [Rif. 35] Delayed reactions to foods: Food allergy and rheumatic disease- Panush R.S. et al - Ann Allergy 56:500-3, 1986
• [Rif. 36] Influence of fasting on intestinal permeabilità and disease activity in patients with rheumatoid arthritis shows normalization durino fasting - Sundquist T., Lindstrom F., Magnusson K. And Skoldstam L. - Scand J Rheumatol 11:33-38, 1982
• [Rif. 37] La psoriasi si cura nell’intestino - Vito Massaro - 15/11/2008
• [Rif. 38] Malabsorption in psoriatic patients: cause or consequence? - Ojetti V, De Simone C, Aguilar Sanchez J, Capizzi R, Migneco A, Guerriero C, Cazzato A, Gasbarrini G, Amerio P, Gasbarrini A - Scand J Gastroenterol - 41(11):1267-71, 11/2006 (PMID: 17060119 [PubMed - indexed for MEDLINE])
• [Rif. 39] Medical nutrition therapy as a potential complementary treatment for psoriasis--five case reports - Brown AC, Hairfield M, Richards DG, McMillin DL, Mein EA, Nelson CD - Altern Med Rev - 9(3):297-307 - 09/2004
• [Rif. 40] Microscopic inflammatory changes in colon of patients with both active psoriasis and psoriatic arthritis without bowel symptoms - Scarpa R, Manguso F, D'Arienzo A, D'Armiento FP, Astarita C, Mazzacca G, Ayala F- J Rheumatol - 27(5):1241-6 - 05/2000
• [Rif. 41] Intestinal permeability in patients with psoriasis - Humbert P, Bidet A, Treffel P, Drobacheff C, Agache P - J Dermatol Sci. - 2(4):324-6 - 07/1991
• [Rif. 42] Autointoxication revisited - Person JR, Bernhard JD - J Am Acad Dermatol - 15(3):559-63 - 09/1986
• [Rif. 43] Small intestinal permeability in dermatological disease - Hamilton I, Fairris GM, Rothwell J, Cunliffe WJ, Dixon MF, Axon AT - Q J Med. - 56(221):559-67 - 09/1985

Test per riconoscere una Leaky Gut Syndrome

Siti WEB:

• [Rif. 44] www.leakygut.co.uk/testing.htm/
• [Rif. 45] www.ei-resource.org/functional-laboratory-tests/gastrointestinal/intestinal-permeability-test/
• [Rif. 46] www.ei-resource.org/functional-laboratory-tests/gastrointestinal/intestinal-permeability-test/
• Pubblicazioni su riviste scientifiche
• [Rif. 47] Estratto del CCN Digestive Wellness - 3° Edizione - Cap. 6 “Leak Gut Sindrome: The Systemic Consequences of Faulty Digestion” - Liz Lipski - Ed. MCGraw Hill, 1998
• [Rif. 48] Gut Permeability measured by polyethylene glycol absorption in abnormal gut fermentation as compared with food intolerance - K.K.Eaton, M.Howard, J.M.H.McLaren Howard
• [Rif. 49] Leaky Gut Sindrome: A modern Epidemic - Leo Galland, MD, FACN - Toensend Letter for Doctors, August/September,1995
• [Rif. 50] The Healing Power of Food - Michael Murray - Prima Publishing, Rocklin, California,1993
• [Rif. 51] Enciclopedia of Natural Medicine - Michael Murray, Joseph Pizzorno - Prima Publishing, Rockland, California,1998

Trattamenti della Leaky Gut Syndrome

Siti WEB:

• [Rif. 52] www.leakygut.co.uk/Treatments%20for%20leaky%20gut.htm
• [Rif. 53] www.ei-resource.org/treatment-options/treatment-information/leaky-gut-syndrome-treatment/
• [Rif. 54] www.ei-resource.org/treatment-options/treatment-information/antioxidants-and-liver-supplements/
• [Rif. 55] www.nutratec.it/upload/file/IT040201_Klamath.pdf
• [Rif. 56] www.nutriterapia.it/pdf/studisulleklamath.PDF; www.origininaturali.it/custompage.php~link~3STUDI+SCIENTIFICI+SULL'+ALGA+KLAMATH~.html

Pubblicazioni su riviste scientifiche:

• [Rif. 57] Fasting, intestinal permeability and rheumatoid arthritis - L. Skoldstam, K. E. Magnusson - Rheum Dis Clin N Amer 17:363-71, 1991
• [Rif. 58] NEJ Medicine; 333(13):839-844, 28/09/1995
• [Rif. 59] Evaluation of zinc status in subjects with Crohn's disease - Sjogren A, Floren CH, Nilsson A - J Am Coll Nutr.;7:57-60,1988
• [Rif. 60] Effect of zinc therapy on natural killer cell activity in inflammatory bowel disease - Van de Wal Y, Van der Sluys Veer A, Verspaget HW, et al. - Aliment Pharmacol Ther.;7:281-286, 1993
• [Rif. 61] Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel disease - Mulder TP, van der Sluys Veer A, Verspaget HW, et al. J - Gastroenterol Hepatol.;9:472-477, 1994
• [Rif. 62] Zinc in ulcerative colitis: a therapeutic trial and report on plasma levels -Dronfield MW, Malone JD, Langman MJ - Gut.;18:33-36,1977
• [Rif. 63] Hall JC et al. - Br J Surg; 83(3):305-312; 03/1996
• [Rif. 64] Int. J. Parasitol; 1-2(8):941-944, 1991
• [Rif. 65] Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways -World J Gastroenterol - 11(41):6450-8 - 11/2005
• Brzozowski T, Konturek PC, Drozdowicz D, Konturek SJ, Zayachivska O, Pajdo R, Kwiecien S, Pawlik WW, Hahn EG - Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
• [Rif. 66] The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity - Heggers JP, Cottingham J, Gusman J, Reagor L, McCoy L, Carino E, Cox R, Zhao JG - J. Altern Complement Med. - 8(3):333-400 - 6/2002
• [Rif. 67] The role of diary foods containing bifido and acidophilus bacteria in nutrition and health - Rasic, JL - N Eur Dairy J; 1983; 4:80-88

Libri ed E-book sull’argomento:

• [Rif. 68] Leaky Gut Syndrome - Elisabeth Lpsky, M.S. C.C.N, Ed. Good Healt Guides, 1998.
• [Rif. 69] How to beat Leaky Gut Syndrome - Philip Jones - June 2006 (E-Book)
• [Rif. 70] One Cause, Many Aliments: Leaky Gut Syndrome - What It Is and How It May Be Affecting Your Health - Dr. John O.A. Pagano, Ed. John Wiley & Sons, Ottobre 2008
• [Rif. 71] Intolleranze Alimentari - Dott. Alessandro Targhetta, Ed. Il punto d’Incontro, Ottobre 2007
• [Rif. 72] Benessere Totale - Joseph Pizzorno, Ed. Tecniche Nuove, Giugno 2001