La Leaky Gut Syndrome in ottica naturopatica
- Autore/autrice
- Petrosillo Roberta
- Anno
- 2024
- Numero
- 1944
Abstract
La Leaky Gut Syndrome (sindome dell'intestino permeabile) è una condizione in cui la barriera intestinale diventa disfunzionale, permettendo il passaggio di molecole tossiche e batteri nel flusso sanguigno. Questo fenomeno è associato a infiammazione cronica e allo sviluppo di diverse patologie sistemiche, tra cui malattie autoimmuni, metaboliche e neurologiche. La tesi indaga il ruolo centrale dell'intestino nella salute umana, esplorando come il suo malfunzionamento possa essere la causa primaria di numerose malattie, in linea con il principio causalista della naturopatia.
Un'attenzione particolare viene data al lavoro del Dr. Alessio Fasano, la cui scoperta della zonulina, una proteina che regola la permeabilità intestinale, ha fornito nuove comprensioni sui meccanismi alla base della Leaky Gut Syndrome. Si esplorano inoltre gli studi della Dott.ssa Elisabeth Lipski, che collega la nutrizione alla salute intestinale, dimostrando come specifici protocolli dietetici possano ripristinare l'integrità della barriera intestinale.
La tesi non si limita però alla visione della medicina occidentale, ma integra anche la prospettiva della Medicina Tradizionale Cinese, del Fisiomedicalismo, della Naturopatia e dell'Iridologia.
Fonti
Bibliografia e Sitografia:
- Bäckhed, F., et al. (2005). “Host-bacterial mutualism in the human intestine.” Science, 307(5717), 1915-1920. https://doi.org/10.1126/science.1104816
- Bäckhed, F., et al. (2012). “Mechanisms Underlying the Resistance to Diet-Induced Obesity in Germ-Free Mice.” PNAS, 108(1): 1034-1038.
- Bercik, P., et al. (2011). “The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.” Gastroenterology, 141(2), 599-609. https://doi.org/10.1053/j.gastro.2011.04.052
- Berkman, D. S., et al. (2002). “Effects of Giardia Lamblia Infection on Growth and Intestinal Permeability in Pre-School Children in Northeast Brazil.” Pediatric Infectious Disease Journal, 21(4): 319-322.
- Bernard Jensen. (1998). Iridology: The Science and Practice in the Healing Arts. Bernard Jensen International.
- Bischoff, S. C., et al. (2014). “Intestinal permeability - a new target for disease prevention and therapy.” BMC Gastroenterology, 14, 189. https://doi.org/10.1186/s12876-014-0189-7
- Blaut, M., & Clavel, T. (2007). “Metabolic diversity of the intestinal microbiota: Implications for health and disease.” Journal of Nutrition, 137(3), 751S-755S. https://doi.org/10.1093/jn/137.3.751S
- Binda, C., Lopetuso, L. R., Rizzatti, G., et al. (2020). “Gut microbiota modulation for multidrug-resistant organism decolonization: Present and future perspectives.” Frontiers in Microbiology, 11, 1373.https://doi.org/10.3389/fmicb.2020.01373
- Boulangé, C. L., et al. (2016). “Impact of the gut microbiota on inflammation, obesity, and metabolic disease.” Genome Medicine, 8(1), 42. https://doi.org/10.1186/s13073-016-0303-2
- Cani, P. D., & Delzenne, N. M. (2009). “The role of the gut microbiota in energy metabolism and metabolic disease.” Current Pharmaceutical Design, 15(13), 1546-1558. https://doi.org/10.2174/138161209788168164
- Chaitow, L., & Trenev, N. (2011). Probiotics: How Live Yogurt and Other ‘Friendly’ Bacteria Can Restore Health and Vitality. HarperCollins Publishers.
- Clarke, G., et al. (2013). “The microbiome-gut-brain axis during early-life regulates the hippocampal serotonergic system in a sex-dependent manner.” Molecular Psychiatry, 18(6), 666-673. https://doi.org/10.1038/mp.2012.77
- Collins, S. M., Surette, M., & Bercik, P. (2012). “The interplay between the intestinal microbiota and the brain.” Nature Reviews Microbiology, 10(11), 735-742. https://doi.org/10.1038/nrmicro2876
- Ciorba, M. A. (2012). “A gastroenterologist’s guide to probiotics.” Clinical Gastroenterology and Hepatology, 10(9), 960-968. https://doi.org/10.1016/j.cgh.2012.03.024
- Cui, J., et al. (2014). “Antifungal Treatments for Small Intestinal Fungal Overgrowth: Systematic Review and Meta-Analysis.” World Journal of Gastroenterology, 20(6): 1907-1915.
- De Palma, G., et al. (2014). “Intestinal Dysbiosis and Allergic Diseases: A Focus on the Gut Microbiota-Immune System Link.” Current Opinion in Immunology, 31: 16-22.
- De Palma, G., et al. (2017). “Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice.” Science Translational Medicine, 9(379). https://doi.org/10.1126/scitranslmed.aaf6397
- De Punder, K., & Pruimboom, L. (2015). “Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability.” Frontiers in Immunology, 6, 223. https://doi.org/10.3389/fimmu.2015.00223
- Drago, S., El Asmar, R., Di Pierro, M., Grazia Clemente, M., Sapone, A., & Fasano, A. (2006). “Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines.” Scandinavian Journal of Gastroenterology, 41(4), 408-419. https:// doi.org/10.1080/00365520500235334
- Everard, A., & Cani, P. D. (2013). “Gut microbiota and GLP-1.” Vitamins and Hormones, 91, 295-320. https://doi.org/10.1016/ B978-0-12-407766-9.00012-1
- Fasano, A. (2011). “Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer.” Physiological Reviews, 91(1), 151-175. https://doi.org/10.1152/physrev.00003.2008
- Fasano, A. (2012). “Leaky gut and autoimmune diseases.” Clinical Reviews in Allergy & Immunology, 42(1), 71-78. https://doi.org/10.1007/s12016-011-8291-x
- Foster, J. A., & McVey Neufeld, K. A. (2013). “Gut-brain axis: How the microbiome influences anxiety and depression.” Trends in Neurosciences, 36(5), 305-312. https://doi.org/10.1016/j.tins.2013.01.005
- Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011). “Intestinal microbiota in human health and disease: The impact of probiotics.” Genes & Nutrition, 6(3), 209-240. https://doi.org/10.1007/s12263-011-0229-7
- Ghoshal, U. C., et al. (2017). “Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge Between Functional and Organic Disorders.” Gastroenterology & Hepatology, 13(8): 472-483.
- Ghouri, Y. A., Richards, D. M., Rahimi, E. F., et al. (2014). “Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease.” Clinical and Experimental Gastroenterology, 7, 473-487. https://doi.org/10.2147/CEG.S27530
- Gutiérrez, R. M. P., Mitchell, S., & Solis, R. V. (2008). “Psidium guajava: A review of its traditional uses, phytochemistry, and pharmacology.” Journal of Ethnopharmacology, 117(1), 1-27. https:// doi.org/10.1016/j.jep.2008.01.025
- Hemarajata, P., & Versalovic, J. (2013). “Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation.” Therapeutic Advances in Gastroenterology, 6(1), 39-51. https://doi.org/10.1177/1756283X12459294
- Herbert, D., Singh, N., & Manoharan, R. (2014). “Modulating the immune system: The role of probiotics in regulating inflammation and autoimmunity.” Frontiers in Immunology, 5, 140. https://doi.org/10.3389/fimmu.2014.00140
- Hollander, D. (1999). “Intestinal permeability, leaky gut, and intestinal disorders.” Current Gastroenterology Reports, 1(5), 410-416. https://doi.org/10.1007/s11894-999-0010-5
- Honda, K., & Littman, D. R. (2012). “The microbiota in adaptive immune homeostasis and disease.” Nature, 535(7610), 75-84. https://doi.org/10.1038/nature18848
- Jensen, G. S., Patterson, K. M., & Barnes, J. (2014). “Endotoxemia and gut barrier dysfunction: Induced by high fat diet, obesity, and leaky gut.” Journal of Evidence-Based Complementary & Alternative Medic ine, 19(4), 280-288. https://doi.org/10.1177/2156587214532701
- Kostic, A. D., Howitt, M. R., & Garrett, W. S. (2013). “Exploring host-microbiota interactions in animal models and humans.” Genes & Development, 27(7), 701-718. https://doi.org/10.1101/gad.212522.112
- Krumbeck, J. A., Maldonado-Gomez, M. X., Ramer-Tait, A. E., & Hutkins, R. W. (2016). “Prebiotics and synbiotics: Dietary strategies forimproving gut health.” Current Opinion in Gastroenterology, 32(2), 110-119. https://doi.org/10.1097/MOG.0000000000000232
- Lerner, A., & Matthias, T. (2015). “Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease.” Autoimmunity Reviews, 14(6), 479-489. https://doi.org/10.1016/j.autrev.2015.01.009
- Leber, A., Amann, N., & Müthing, J. (2021). “Probiotics in gastrointestinal diseases.” Microorganisms, 9(1), 11. https://doi.org/10.3390/microorganisms9010011
- Lomer, M. C. E., Parkes, G. C., & Sanderson, J. D. (2008). “Lactose intolerance in clinical practice - myths and realities.” Alimentary Pharmacology & Therapeutics, 27(2), 93-103. https://doi.org/10.1111/j.1365-2036.2007.03557.x
- Marakalala, M. J., et al. (2014). “Immunometabolic Regulation of Antifungal Immunity.” Cell Host & Microbe, 15(1): 19-25.
- Marchesi, J. R., & Ravel, J. (2015). “The vocabulary of microbiome research: A proposal.” Microbiome, 3(31), 1-6. https://doi.org/10.1186/s40168-015-0094-5
- Marchesi, J. R., et al. (2016). “The gut microbiota and host health: A new clinical frontier.” Gut, 65(2), 330-339. https://doi.org/10.1136/gutjnl-2015-309990
- Marteau, P., & Seksik, P. (2013). “Probiotics and health: New facts and ideas.” Current Opinion in Biotechnology, 24(2), 186-192.https://doi.org/10.1016/j.copbio.2013.03.012
- Mayer, E. A., Savidge, T., & Shulman, R. J. (2014). “Brain-gut microbiome interact ions and funct ional bowel disorders.”Gastroenterology, 146(6), 1500-1512. https://doi.org/10.1053/j.gastro.2014.02.037
- Mayer, E. A., Tillisch, K., & Gupta, A. (2015). “Gut/brain axis and the microbiota.” The Journal of Clinical Investigation, 125(3),926-938. https://doi.org/10.1172/JCI76304
- McFarland, L. V. (2015). “Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: A systematic review.” BMJ Open, 5(1), e008914. https://doi.org/10.1136/bmjopen-2015-008914
- Mu, Q., et al. (2017). “Leaky gut as a danger signal for autoimmune diseases.” Frontiers in Immunology, 8, 598. https://doi.org/10.3389/fimmu.2017.00598